Bilateral Mandibular and Bilateral Maxillary Cancer: A Rare Case of Tumor Metastases from The Breast
DOI:
https://doi.org/10.70019/ahas.v1i1.31Abstract
Tumor metastases are very rare causes of jaw lesions. Previous reports have indicated occurrence in one or more quadrants, but metastatic lesions in all four quadrants are exceptionally rare. This study aimed to report an unusual presentation of metastatic carcinoma, in which metastatic deposits from the breast were found on the four quadrants of the jawbones. We present an unusual case of metastatic lesion from the breast to the mandible and maxilla bilaterally in a 46-year-old woman. The patient was admitted to a previous treatment of breast cancer only after several promptings. The clinical and microscopic features of the jaw lesions and the microscopic features of the breast lesion are presented with a review of the pertinent literature.
References
Klein CA (2008) Cancer. The metastasis cascade. Science 321: 1785-1787. doi: 10.1126/science.1164
Greenlee RT, Hill-Harmon MB, Murray T, Thun M (2001) Cancer statistics. Cancer J Clin 51: 15-36. 15-36. http://dx.doi.org/10.3322/canjclin.51.1.15
Jin X, Mu P (2015);. Targeting breast cancer metastasis. Breast Cancer (Auckl). 9 (Suppl 1):23-34. doi: 10.4137/BCBCR.S25460
Adisa A, Arowolo O, Akinkuolie A (2011), et al. Metastatic breast cancer in a Nigerian tertiary hospital. Afr Health Sci.;11 (2):279–284. doi:10.4314/ahs.v11i2.68458
Wuraola FO, Famurewa BA, Olasehinde O, Odujoko OO, Adesina OM, Aregbesola SB (2021). From the breast to the upper jaw: A rare case of metastatic breast cancer. South Sudan Medical Journal; 14(2):60-63. doi: 10.1055/s-0044-1779674
Dib LL, Soares AL, Sandoval RL, Nannmark U (2007): Breast metastasis around dental implants: a case report. Clin Implant Dent Relat Res, 9:112-115. doi:10.1111/j.1708-8208.2007.00033.x
Tenzer JA, Rypins RD, Jakowatz JG (1988). Malignant cystosarcoma phyllodes metastatic to the maxilla. J Oral Maxillofac Surg.; 46 (1):80–82. doi: 10.1016/0278-2391(88)90307-2
Poulias E, Melakopoulos I, Tosios K (2011). Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report. J Med Case Rep.;5:265. doi: 10.1186/1752-1947-5-265
Friedrich RE, Abadi M (2010). Distant metastases and malignant cellular neoplasms encountered in the oral and maxillofacial region: analysis of 92 patients treated at a single institution. Anticancer Res. 30:1843–8. doi: 10.1016/j.joms.2009.04.065.
Hirshberg A, Buchner A (1995) Metastatic tumours to the oral region. An overview. Eur J Cancer B Oral Oncol 31B: 355-360. doi: 10.1016/0964-1955(95)00031-3.
D'Silva NJ, Summerlin DJ, Cordell KG, Abdelsayed RA, Tomich CE, Hanks CT Fear D, Meyrowitz S (2006): Metastatic tumors in the jaws: a retrospective study of 114 cases. J Am Dent Assoc, 137:1667-1672. doi: 10.14219/jada.archive.2006.0112
Akinbami BO(2009). Metastatic carcinoma of the jaws: a review of literature. Niger J Med, 18:139-142. doi: 10.1186/1752-1947-5-265
Lesnick JA, Zallen RD: Numb chin syndrome secondary to metastatic breast disease. J Colo Dent Assoc 1999, 78:11-14. PMID: 10686889.
Miyazaki et al. (2022) Breast carcinoma metastasis to the cheek: a case report. Journal of Medical Case Reports 16:108. https://doi.org/10.1186/s13256-022-03326-6
Poulias E, Melakopoulos I and Tosios K (2011). Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report; Journal of Medical Case Reports 5:265. doi: 10.1186/1752-1947-5-265
Selden HS, Manhoff DT, Hatges NA, Michel RC (1998). Metastatic carcinoma to the mandible that mimicked pulpal/periodontal disease. J Endod;24:267 70. doi: 10.1016/s0099-2399(98)80111-8.
Boyczuk EM, Solomon MP, Gold BD (1991). Unremitting pain to the mandible secondary to metastatic breast cancer: A case report. Compendium;12:104, 106, 108 10. PMID: 1860117.
Ogutcen Toller M, Metin M, Yildiz L (2002). Metastatic breast carcinoma mimicking periodontal disease on radiographs. J Clin Periodontol;29:269 71. https://doi.org/10.1034/j.1600-051x.2002.290314.x
Pruckmayer M, Glaser C, Marosi C, Leitha T (1998). Mandibular pain as the leading clinical symptom for metastatic disease: Nine cases and review of the literature. Ann Oncol. 9:559 64. doi: 10.1023/a:1008286117771.
Van der Waal RI, Buter J, van der Waal I (2003). Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg. 41:3–6. https://doi.org/10.1016/S0266-4356(02)00301-7
Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R (2008). Metastatic tumours to the oral cavity—pathogenesis and analysis of 673 cases. Oral Oncol.;44:743–52. doi: 10.1016/j.oraloncology.2007.09.012
Stavropoulos MF, Ord RA (1993). Lobular adenocarcinoma of breast metastatic to the mandibular condyle. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol. 75 (5):575–578. doi: 10.1016/0030-4220(93)90227-u.
Adelusi E.A., Olaniran F.O. and Babarinde T.O. (2023). Exodus of Nigerian Medical Professionals from Nigeria: Looming Danger Incubating!. J Dent & Oral Health. 7(3): doi: 10.33552/OJDOH.2023.07.000661.
Varghese G, Singh SP, Sreela LS (2014). A rare case of breast carcinoma metastasis to mandible and vertebrae. Natl J Maxillofac Surg;5 (2):184- 187. doi: 10.4103/0975-5950.154832
Cherny NI, Paluch-Shimon S, Berner-Wygoda Y (2018). Palliative care: needs of advanced breast cancer patients. Breast Cancer (Dove Med Press).;10:231-243. doi: 10.2147/BCTT.S160462
Hirshberg A, Leibovich P, Buchner A (1994). Metastatic tumors to the jawbones: analysis of 390 cases. J Oral Pathol Med 23:337-341. DOI: 10.1111/j.1600-0714.1994.tb00072.x
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Annals of Health and Allied Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
